Stem Cells

doi:10.1093/ champion/awh553 Brain (2005), 128, 20342041 Cerebral small-vessel disease and heretofore out in information affect speed, executive act upon and memory Niels D. Prins,1,2 Ewoud J. van Dijk,1,2 Tom retreat Heijer,1,2 Sarah E. Vermeer,1,2 Jellemer Jolles,3 Peter J. Koudstaal,1 Albert Hofman2 and Monique M. B. Breteler2 1 3 Department of Neurology and 2Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam and Department of Neuropsychology, psychological medicine and Psychobiology, University of Maastricht, Maastricht, The Netherlands Cerebral small-vessel disease is common in ripened hoi polloi and may contribute to the development of dementia. The objective of the present think was to evaluate the relationship amid measures of intellectual small-vessel disease on MRI and the post of change state in speci?c cognitive domains in participants from the prospective, population-based Rotterdam Scan Study. Participants w ere 6090 old age of season and free from dementia at baseline in 19951996. White subject field lesions (WML), cerebral infarcts and generalized brain atrophy were assessed on the baseline MRI. We performed neuropsychological testing at baseline and reiterately in 19992000 and in 20012003.

We used random-effects models for repeated measures to examine the association between vicenary MRI measures and rate of go down in measures of global cognitive function, information processing speed, executive function and memory. There were a total of 2266 judgings for the 832 participants in the study, with an average time fr om the initial to in the end assessment of ! 5.2 years. Increasing severity of periventricular WML and generalized brain atrophy and the apparent movement man of brain infarcts on MRI were associated with a bold decline in cognitive function. These structural brain changes were speci?cally associated with decline in information processing speed and executive function. The associations between MRI measures of cerebral small-vessel...If you want to get a rise essay, order it on our website: OrderCustomPaper.com

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